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Embryo aneuploidy screening for unexplained recurrent miscarriage: a minireview.
Carmen Rubio1, Tugce Pehlivan, Lorena Rodrigo
1Instituto Valenciano de Infertilidad (IVI), University of Valencia, Spain.
Summary
Unexplained recurrent miscarriage (RM) is linked to more chromosomally abnormal embryos. Pre-implantation genetic diagnosis (PGD) with in vitro fertilization (IVF) can improve pregnancy outcomes for affected couples.
Area of Science:
- Reproductive Medicine
- Genetics
- Embryology
Background:
- Recurrent miscarriage (RM) affects couples trying to conceive.
- Chromosomal abnormalities are a suspected cause of RM.
- Pre-implantation genetic diagnosis (PGD) offers a potential solution.
Purpose of the Study:
- To determine the rate of chromosomal abnormalities in unexplained RM patients.
- To evaluate the effectiveness of PGD in improving pregnancy outcomes for RM patients.
Main Methods:
- PGD was conducted in 241 RM cycles and 35 control cycles.
- Specific chromosomes (13, 16, 18, 21, 22, X, Y) were analyzed using fluorescence in situ hybridization (FISH).
Main Results:
- RM patients had higher implantation (26.4%) and pregnancy rates (36.5%) compared to controls (20.6% and 29.0%).
- A significantly higher percentage of abnormal embryos was observed in RM patients.
Conclusions:
- RM is associated with an increased incidence of chromosomally abnormal embryos.
- In vitro fertilization (IVF) combined with PGD is crucial for managing couples experiencing RM.