Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Nitrates.

M Kuhn

    AACN Clinical Issues in Critical Care Nursing
    |May 1, 1992
    PubMed
    Summary
    This summary is machine-generated.

    Nitrate therapy, used for over a century for angina, now also treats heart failure and hypertension by relaxing blood vessels. Effective use requires monitoring hemodynamic responses and potential adverse effects.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    International interlaboratory study to normalize liquid chromatography-based mycotoxin retention times through implementation of a retention index system.

    Journal of chromatography. A·2025
    Same author

    Positive behavior support (PBS) with children with fetal alcohol spectrum disorders: Characterizing caregivers' use of PBS using follow-up clinical trial data.

    Research in developmental disabilities·2024
    Same author

    Riding the waves from epidemic to endemic: Viral mutations, immunological change and policy responses.

    Theoretical population biology·2024
    Same author

    The hammer and the jab: Are COVID-19 lockdowns and vaccinations complements or substitutes?

    European journal of operational research·2023
    Same author

    Incidence of fatigue associated with immune checkpoint inhibitors in patients with cancer: a meta-analysis.

    ESMO open·2022
    Same author

    Effectiveness of Child-Focused Interventions for Externalizing Behavior: a Rapid Evidence Review.

    Research on child and adolescent psychopathology·2022

    Area of Science:

    • Cardiovascular Medicine
    • Pharmacology

    Background:

    • Nitrates have a long history (130 years) in treating angina pectoris.
    • Recent research (15 years) highlights their benefits in heart failure, cardiogenic shock, and hypertensive emergencies.

    Purpose of the Study:

    • To review the physiological mechanisms of nitrate therapy.
    • To outline appropriate indications and specific agent usefulness.
    • To discuss nursing implications for nitrate administration.

    Main Methods:

    • Review of physiological mechanisms of smooth muscle relaxation and vasodilation.
    • Analysis of clinical evidence for nitrate efficacy in various cardiovascular conditions.
    • Discussion of hemodynamic monitoring and adverse event management.

    Related Experiment Videos

    Main Results:

    • Nitrates induce vasodilation by relaxing vascular smooth muscle, reducing preload and afterload.
    • Demonstrated efficacy in angina, severe heart failure, cardiogenic shock, and hypertensive episodes.
    • Adequate use necessitates hemodynamic monitoring and vigilance for adverse effects.

    Conclusions:

    • Nitrate therapy is versatile, extending beyond angina to critical cardiovascular conditions.
    • Understanding mechanisms and monitoring is key for safe and effective nitrate use.
    • Nursing implications are crucial for optimizing patient outcomes with nitrates.