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Updated: Aug 19, 2026
Two-vessel Occlusion Mouse Model of Cerebral Ischemia-reperfusion
Published on: March 1, 2019
[Vascular endothelial growth factor expression in focal cerebral ischemia/reperfusion in injury in rats]
Ying Xing1, Zhong-xin Xu, Jing Mang
1Department of Neurology, China - Japan Union Hospital, Jilin University, Changchun, China.
Objective:
To study the vascular endothelial growth factor (VEGF) expression and its role in focal cerebral ischemia/reperfusion injury.
Methods:
VEGF protein and mRNA expressions at the site of focal ischemia/reperfusion of rat cerebrum were assessed with immunohistochemistry and hybridization techniques.
Results:
In normal cerebral tissue there was lower expression of VEGF. It was found to be expressed in the penumbra area after ischemia. With the prolongation of ischemia and ischemia/reperfusion, enhanced expression of VEGF tended to decline to normal level, while it enhanced in the penumbra area.
Conclusion:
Enhanced VEGF expression might play a protective role in focal ischemia/reperfusion injury to the cerebrum.
