Milk and yoghurt do not impair the absorption of ofloxacin

The effects of milk and yoghurt on the oral absorption of ofloxacin were studied in seven healthy volunteers in a randomized cross-over trial. After an overnight fast, 200 mg ofloxacin was given with 300 ml water, milk or yoghurt. Plasma concentrations and urinary excretion of ofloxacin were determined up to 24 h. Values of total plasma AUC and 24 h urinary excretion of ofloxacin were not affected by milk or yoghurt. Plasma ofloxacin concentrations from 0.5 to 1.5 h and the peak concentration were lower (P less than 0.05) after yoghurt than without and the time to peak was prolonged by 1 h (P less than 0.05).