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Updated: Aug 19, 2026

Plasmodium falciparum Gametocyte Culture and Mosquito Infection Through Artificial Membrane Feeding
Published on: July 3, 2020
Implication of a Plasmodium falciparum gene in the switch between asexual reproduction and gametocytogenesis
Donald L Gardiner1, Matthew W A Dixon, Tobias Spielmann
1Malaria Biology Laboratory, The Australian Centre for International and Tropical Health and Nutrition, The Queensland Institute of Medical Research, 300 Herston Road, Herston, Qld 4006, Australia. dong@qimr.edu.au
Abstract:
Gametocytogenesis is fundamental for transmission of the malaria parasite Plasmodium falciparum from the human host to the mosquito vector, yet very little is understood about what triggers the switch between asexual reproduction and gametocytogenesis. Arresting the progression through the sexual cycle would block transmission of this disease. Here we identify a novel gene in P. falciparum that when genetically silenced reduces gametocyte production by a factor of 6, and when complemented up-regulates gametocyte-specific gene transcription.
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