Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Drugs affecting plasma fibrinogen levels.

G di Minno1, M Mancini

  • 1Clinica Medica, Nuovo Policlinico, Napoli, Italy.

Cardiovascular Drugs and Therapy
|February 1, 1992
PubMed
Summary

High plasma fibrinogen levels predict cardiovascular events like stroke. While several substances lower fibrinogen, the exact mechanisms involving interleukin-6 (IL-6) and monocytes remain unclear.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Is there a multidisciplinary role for 5-methyltetrahydrofolate? The obstetric evidence in perspective.

European review for medical and pharmacological sciences·2024
Same author

Clinical course of patients with symptomatic isolated superficial vein thrombosis: the ICARO follow-up study.

Journal of thrombosis and haemostasis : JTH·2017
Same author

Correlation between FIX genotype and pharmacokinetics of Nonacog alpha according to a multicentre Italian study.

Haemophilia : the official journal of the World Federation of Hemophilia·2016
Same author

Prevalence of deep vein thrombosis and pulmonary embolism in patients with superficial vein thrombosis: a systematic review and meta-analysis.

Journal of thrombosis and haemostasis : JTH·2016
Same author

Biosimilars of low-molecular-weight heparin products: fostering competition or reducing 'biodiversity'?

Journal of thrombosis and haemostasis : JTH·2015
Same author

A clinical score to rule out the concomitant presence of deep vein thrombosis in patients presenting with superficial vein thrombosis: The ICARO study.

Thrombosis research·2015

Area of Science:

  • Cardiovascular Medicine
  • Hematology
  • Immunology

Background:

  • High plasma fibrinogen is a predictor of stroke and myocardial infarction.
  • Plasma fibrinogen is synthesized in the liver, influenced by interleukin-6 (IL-6) produced by monocytes.
  • Several agents, including N-3 fatty acids and alcohol, reduce plasma fibrinogen, but mechanisms are unclear.

Purpose of the Study:

  • To explore the regulatory mechanisms of plasma fibrinogen synthesis and reduction.
  • To investigate the role of IL-6 and monocytes in fibrinogen regulation.
  • To determine if high fibrinogen reflects atherosclerotic damage severity.

Main Methods:

  • Review of current literature on fibrinogen synthesis and regulation.
  • Analysis of the potential impact of IL-6 and monocyte activity on fibrinogen levels.
  • Examination of epidemiological data linking plasma fibrinogen to cardiovascular risk.

Main Results:

  • Interleukin-6 (IL-6) plays a role in regulating plasma fibrinogen synthesis.
  • The precise mechanisms by which various substances lower fibrinogen are not fully understood.
  • Evidence is inconclusive on whether high fibrinogen directly reflects atherosclerotic damage severity.

Conclusions:

  • Plasma fibrinogen measurement should be part of cardiovascular risk assessment.
  • Further population-based studies are needed to elucidate fibrinogen regulation and its role in atherosclerosis.
  • Understanding fibrinogen regulation may reveal new therapeutic targets for cardiovascular disease.

Related Experiment Videos