Related Experiment Video
Updated: Aug 11, 2026

Application of Biochip Microfluidic Technology to Detect Serum Allergen-specific Immunoglobulin E (sIgE)
Published on: April 21, 2019
Sensitivity and specificity-like measures of the validity of a diagnostic test that are corrected for chance
1Department of Medicine, Georgetown University School of Medicine, Washington, DC.
Abstract:
Chance agreement may account for a sizeable proportion of the specificity of a screening test when the disease prevalence is low. Conversely, the observed sensitivity may be largely accounted for by chance agreement when the prevalence of disease is high. We derive descriptive statistics that are analogous to sensitivity and specificity and corrected for the agreement expected by chance. These coefficients of validity are shown to be dependent on the true prevalence of disease, as well as sensitivity and specificity.
Related Concept Videos
Accuracy and Precision
Statistical Analysis: Overview
One of the most commonly used statistical quantifiers is the mean, which is the ratio between the sum of the numerical values of all results and the...
Accuracy and Precision
Accuracy and Errors in Hypothesis Testing
In hypothesis testing, the probability of making a Type I error, denoted as α, is commonly set at 0.05. This significance level indicates a 5% chance...
Sensitivity, Specificity, and Predicted Value
Sensitivity is the...
Receiver Operating Characteristic Plot

