Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Aliphatic polyesters: great degradable polymers that cannot do everything.

Michel Vert1

  • 1Research Centre for Artificial Biopolymers, UMR CNRS 5473, University Montpellier 1, Faculty of Pharmacy, 15 Avenue Charles Flahault, BP 14491, F-34093 Montpellier Cedex 05, France.

Biomacromolecules
|March 15, 2005
PubMed
Summary

Aliphatic polyesters are useful degradable polymers, especially those generating metabolites like poly(beta-hydroxy alkanoates). However, balancing degradation for biological systems with practical application requirements remains a significant challenge.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The non-specific antiviral activity of polysulfates to fight SARS-CoV-2, its mutants and viruses with cationic spikes.

Journal of biomaterials science. Polymer edition·2021
Same author

First-in-Man trial of a drug-free bioresorbable stent designed to minimize the duration of coronary artery scaffolding.

Journal of biomaterials science. Polymer edition·2021
Same author

Hyaluronic Acid-Poly(<i>N</i>-acryloyl glycinamide) Copolymers as Sources of Degradable Thermoresponsive Hydrogels for Therapy.

Gels (Basel, Switzerland)·2020
Same author

Poly[(<i>N</i>-acryloyl glycinamide)-<i>co</i>-(<i>N</i>-acryloyl l-alaninamide)] and Their Ability to Form Thermo-Responsive Hydrogels for Sustained Drug Delivery.

Gels (Basel, Switzerland)·2019
Same author

Comparison of a Drug-Free Early Programmed Dismantling PDLLA Bioresorbable Scaffold and a Metallic Stent in a Porcine Coronary Artery Model at 3-Year Follow-Up.

Journal of the American Heart Association·2017
Same author

A method to slow down the ionization-dependent release of risperidone loaded in a thermoresponsive poly(N-acryloyl glycinamide) hydrogel.

Drug delivery and translational research·2017

Area of Science:

  • Polymer Science
  • Biomaterials Science
  • Environmental Science

Background:

  • Degradable polymers are crucial for various applications, particularly in biological systems.
  • Aliphatic polyesters are of interest due to their sensitivity to hydrolytic degradation in aqueous environments.
  • Few aliphatic polyesters exhibit enzymatic degradability, biodegradability, or biorecyclability.

Purpose of the Study:

  • To evaluate aliphatic polyester structures for their potential in surgery, pharmacology, and environmental applications.
  • To analyze the characteristics of degradable polymers in relation to application-specific requirements.
  • To explore the challenges in developing universally applicable degradable polymers.

Main Methods:

  • Literature review of open and patent sources on degradable polymers.

Related Experiment Videos

  • Analysis of aliphatic polyester structures, focusing on poly(beta-hydroxy alkanoates) and poly(alpha-hydroxy alkanoates).
  • Comparison of polymer characteristics with requirements for surgical, pharmacological, and environmental uses.

    • Main Results:

    • Aliphatic polyesters, particularly poly(beta-hydroxy alkanoates) and poly(alpha-hydroxy alkanoates), show promise due to metabolite generation upon degradation.
    • Degradation, bioresorption, and biorecycling are key targets but also limiting factors for practical devices.
    • No single polymer structure meets all requirements for diverse applications.

    Conclusions:

    • Developing degradable polymers requires balancing degradation properties with application-specific needs.
    • Poly(beta-hydroxy alkanoates) and poly(alpha-hydroxy alkanoates) are promising candidates for specific niches.
    • The search for a universal degradable polymer for all biomaterial needs remains an ongoing challenge.