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Published on: July 1, 2020

[Fungal infections in paediatric patients with chronic granulomatous disease]

P E Santos1, M Oleastro, M Galicchio

  • 1Manuel Quintana 733 Quilmes (Cp.1878), Quilmes Pcia. de Buenos Aires, Argentina. psantos@garra.giga.com.ar

Revista Iberoamericana De Micologia
|March 15, 2005
PubMed

Insights

Patients with chronic granulomatous disease (CGD) face severe fungal infections. This study highlights the high mortality and need for new treatments for these rare mycotic infections in children with CGD.

Area of Science:

  • Immunology
  • Infectious Diseases
  • Pediatrics

Context:

  • Chronic granulomatous disease (CGD) impairs phagocyte function, increasing susceptibility to infections.
  • Mycotic infections pose a significant threat to pediatric patients with CGD.
  • This study reviewed cases from 1988-1998 at a pediatric hospital.

Purpose:

  • To describe the clinical and microbiological characteristics of fungal infections in pediatric CGD patients.
  • To analyze the outcomes and identify challenges in managing these infections.

Summary:

  • Five pediatric CGD patients with mycotic infections were studied, with infections appearing around 8.3 years of age.
  • Common symptoms included fever and lung involvement; disseminated aspergillosis and mixed infections were observed.
  • Diagnosis involved microscopy, culture, and serologic tests.

Impact:

  • Four out of five patients died, underscoring the severity of these infections.
  • The findings emphasize the urgent need for novel therapeutic strategies.
  • Further research into emerging pathogens in CGD patients is crucial.

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