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Histological Quantification to Determine Lung Fungal Burden in Experimental Aspergillosis
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Histological Quantification to Determine Lung Fungal Burden in Experimental Aspergillosis

Published on: March 9, 2018

[Invasive aspergillosis: treatment]

P Saballs-Radresa1, J L López-Colomés, J Gimeno-Cobos

  • 1Hospital del Mar, Passeig Marítim 25-29, 08003 Barcelona, España. 12822@imas.imim.es

Revista Iberoamericana De Micologia
|March 15, 2005
PubMed

Insights

Invasive aspergillosis is a serious fungal infection primarily impacting immunocompromised patients. Early diagnosis and prompt treatment with available or emerging antifungal therapies, alongside potential surgical intervention, are crucial for patient outcomes.

Area of Science:

  • Mycology
  • Infectious Diseases
  • Clinical Pharmacology

Context:

  • Invasive aspergillosis poses a significant threat to immunocompromised individuals, including those with congenital or acquired immunodeficiencies, neutropenia, organ transplants, or undergoing chemotherapy and corticosteroid therapy.
  • Current treatment options for invasive aspergillosis are limited, necessitating a thorough understanding of available antifungals.

Purpose:

  • To provide a comprehensive overview of current and emerging therapeutic strategies for invasive aspergillosis.
  • To emphasize the importance of understanding patient-specific factors, drug pharmacokinetics, and evidence-based treatment criteria.

Summary:

  • The review details existing treatments such as amphotericin B deoxycholate, lipid formulations, and itraconazole, and anticipates the future roles of voriconazole, posaconazole, liposomal nystatin, and echinocandins.
  • It highlights the critical need for high clinical suspicion, rapid initiation of antifungal therapy, and consideration of adjuvant treatments, including surgery for specific manifestations like pulmonary aspergillosis and sinusitis.

Impact:

  • This information is vital for clinicians managing invasive aspergillosis, enabling informed treatment decisions and improved patient management.
  • Optimizing antifungal therapy and surgical interventions can lead to better clinical outcomes and reduced mortality in this vulnerable patient population.

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