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A Linn Murphree1

  • 1The Retinoblastoma Program, Childrens Center for Cancer and Blood Disease, Childrens Hospital Los Angeles, MS 88, 4650 Sunset Boulevard, Los Angeles, CA 90027, USA. lmurphree@chla.usc.edu

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Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...