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Non-depleting anti-CD4 antibody not only prevents onset but resolves sialadenitis in NOD mice
Clare Thompson1, Helle Jacobsen, Daniel Pomeranz Krummel
1Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, UK.
Abstract:
The non-obese diabetic (NOD) mouse spontaneously develops lymphocytic infiltrates in the salivary glands (sialadenitis) and provides an useful rodent model of human Sjogren's syndrome (SS). Non-depleting anti-CD4 antibodies have been shown to ameliorate Type 1 diabetes in NOD mice and also vasculitis in MRL/lpr mice. This study shows that a short course of treatment with the non-depleting anti-CD4 monoclonal antibody, YTS 177, completely prevents salivary infiltration and reverses ongoing pathology in the salivary gland.
