Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Anemia and inflammation in COPD.

Matthias John1, Soeren Hoernig, Wolfram Doehner

  • 1Department of Pneumology, University Hospital Charité, Campus Mitte, Schumannstr. 20/21, 10098 Berlin, Germany. matthias.john@charite.de

Chest
|March 15, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Process Mining for Quality Improvement in Malawi.

Studies in health technology and informatics·2026
Same author

Potassium limits productivity in intensive cereal cropping systems in Southeast Asia.

Nature food·2024
Same author

Feasibility Study on the Use of NO<sub>2</sub> and PM<sub>2.5</sub> Sensors for Exposure Assessment and Indoor Source Apportionment at Fixed Locations.

Sensors (Basel, Switzerland)·2024
Same author

Pneumo news·2023
Same author

Long-term indoor gunshot exposure of special police forces induces bronchitic reactions and elevated blood lead levels-The Berlin shooting range study.

Journal of cachexia, sarcopenia and muscle·2022
Same author

ATR represents a therapeutic vulnerability in clear cell renal cell carcinoma.

JCI insight·2022

Anemia affects 13% of COPD patients, showing high erythropoietin levels and inflammation, suggesting erythropoietin resistance possibly due to chronic illness inflammation.

Area of Science:

  • Pulmonary Medicine
  • Hematology

Background:

  • Anemia in patients with Chronic Obstructive Pulmonary Disease (COPD) and its underlying pathophysiology remain understudied.
  • Understanding anemia in COPD is crucial for patient management.

Purpose of the Study:

  • To determine the prevalence of anemia in COPD patients.
  • To investigate the relationship between anemia and body mass, weight loss, inflammatory markers, and erythropoietin levels in COPD.
  • To identify factors influencing anemia development in COPD.

Main Methods:

  • A study involving 101 COPD patients (FEV1 37% +/- 2%) and a control group of age-matched healthy individuals.
  • Assessment of anemia prevalence, body mass, weight loss, inflammatory parameters, and erythropoietin levels.
  • Comparison of data between anemic and non-anemic COPD patients and the control group.

Related Experiment Videos

Main Results:

  • Anemia prevalence was 13% in the studied COPD population (hemoglobin < 13.5 mg/dL for males, < 12.0 mg/dL for females).
  • Anemic COPD patients exhibited elevated erythropoietin levels (41.8 +/- 25.4 U/L vs 16.3 +/- 2.9 U/L) and increased inflammatory response compared to non-anemic patients.
  • A significant inverse correlation between hemoglobin and erythropoietin was found in anemic COPD patients (r = -0.84, p < 0.01).

Conclusions:

  • Anemic COPD patients demonstrate high erythropoietin levels, suggesting potential erythropoietin resistance.
  • Inflammatory mechanisms, characteristic of anemia of chronic illness, may mediate this erythropoietin resistance in COPD patients.