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Updated: Aug 19, 2026

Peptide-based Identification of Functional Motifs and their Binding Partners
Published on: June 30, 2013
Do oestrogen receptors play a role in the pathogenesis of HIV-associated lipodystrophy?
Luisa Barzon1, Mauro Zamboni, Monia Pacenti
1Departments of Histology, Microbiology and Medical Biotechnologies, University of Padova, Padova, Italy.
Abstract:
Epidemiological data show an increased risk of HIV-associated lipodystrophy in women, and sex hormone abnormalities have been reported with highly active antiretroviral therapy (HAART). This study, which demonstrates that oestrogen receptor beta expression is significantly reduced in the subcutaneous adipose tissue of HIV-infected lipodystrophic patients, downregulated by HAART regimens including protease inhibitors (PI), and restored after switching from PI, opens perspectives for the investigation of selective oestrogen receptor modifiers for the management of this syndrome.
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