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Nutritional status and energy expenditure in children pre-bone-marrow-transplant

M White1, A J Murphy, Y Hastings

  • 1Department of Nutrition and Dietetics, Royal Children's Hospital, Herston, Qld, Australia. Melinda_White@health.qld.gov.au

Bone Marrow Transplantation
|March 15, 2005
PubMed

Insights

Children undergoing bone marrow transplant (BMT) often have poor nutritional status. Body Mass Index (BMI) is not a reliable indicator, but predictive equations accurately estimate resting energy expenditure (REE) in this population.

Area of Science:

  • Pediatric Hematology/Oncology
  • Nutritional Science
  • Clinical Research

Background:

  • Assessing nutritional status in children undergoing bone marrow transplant (BMT) is crucial for treatment outcomes.
  • Existing methods for evaluating nutritional status and energy expenditure may not be accurate in this specific pediatric population.

Purpose of the Study:

  • To determine the nutritional status of children before BMT.
  • To evaluate the accuracy of predictive methods for assessing nutritional status and resting energy expenditure (REE) in pediatric BMT patients.

Main Methods:

  • Analyzed body cell mass (BCM) and REE in children undergoing BMT.
  • Used BCM adjusted for height (BCM/HT(p)) as a Z score for nutritional status.
  • Compared Body Mass Index (BMI) Z scores to BCM/HT(p) Z scores.
  • Compared measured REE to predicted basal metabolic rate (BMR) using Schofield equations.

Main Results:

  • The mean BCM/HT(p) Z score indicated suboptimal nutritional status (-1.09+/-1.28).
  • No significant correlation was found between BMI Z score and BCM/HT(p) Z score (r=0.34; P>0.05).
  • Schofield equations showed minimal bias when predicting REE compared to measured values (bias=-11+/-149 kcal/day).

Conclusions:

  • Children pre-BMT may exhibit suboptimal nutritional status.
  • BMI is an inaccurate indicator of nutritional status in pediatric BMT patients.
  • Schofield equations are suitable for estimating REE in children prior to BMT.

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