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Related Experiment Videos

Propofol for deep procedural sedation in the ED.

Bradley W Frazee1, Robert S Park, Derrick Lowery

  • 1Department of Emergency Medicine, Alameda County Medical Center-Highland Campus, Oakland, CA 94602, USA.

The American Journal of Emergency Medicine
|March 15, 2005
PubMed
Summary

Propofol is effective for emergency department procedural sedation. While well-accepted, this routine use of propofol (2,6-diisopropylphenol) for sedation can lead to adverse events like hypotension and hypoxemia.

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Area of Science:

  • Emergency Medicine
  • Anesthesiology
  • Pharmacology

Background:

  • Procedural sedation in the emergency department (ED) is common.
  • Propofol is an effective anesthetic agent with a rapid onset and short duration of action.
  • Evaluating its routine use for various procedures is important for safety and efficacy.

Purpose of the Study:

  • To assess the efficacy and safety of propofol for procedural sedation in the ED.
  • To determine patient and physician satisfaction with propofol sedation.
  • To identify common adverse events associated with propofol administration.

Main Methods:

  • Prospective observational study in an urban teaching ED.
  • Propofol administered by handheld syringe with fentanyl.

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  • Monitored vital signs, pulse oximetry, adverse events, and satisfaction.

    • Main Results:

    • 136 patients (18-69 years) underwent procedures like abscess incision/drainage and orthopedic reduction.
    • 10.3% experienced adverse events, including hypotension (5), hypoxemia (7), and apnea (5).
    • One patient required intubation; patient and physician satisfaction were excellent.

    Conclusions:

    • ED procedural sedation with propofol is effective and well-accepted.
    • Routine propofol use is associated with a significant incidence of hypotension, hypoxemia, and apnea.
    • Careful monitoring is essential during propofol administration for procedural sedation.