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[Urinary tract infections in children--etiologic agents and susceptibility to antibiotics]

Maria Nowakowska1, Danuta Rogala-Zawada, Barbara Wiechuła

  • 1Katedry i Zakładu Mikrobiologii Lekarskiej, Slaskiej Akademii Medycznej w Katowicach. mikrobiologia@slam.katowice.pl

Wiadomosci Lekarskie (Warsaw, Poland : 1960)
|March 16, 2005
PubMed

Insights

Pediatric urinary tract infections (UTIs) saw an increase in multidrug-resistant Gram-negative rods, particularly ESBL-producing strains, over the study period. These resistant bacteria showed limited treatment options, posing a challenge in pediatric care.

Area of Science:

  • Pediatric Infectious Diseases
  • Clinical Microbiology
  • Hospital Epidemiology

Background:

  • Urinary tract infections (UTIs) are a frequent clinical issue in pediatric healthcare settings.
  • Changes in microbial resistance patterns necessitate ongoing surveillance.

Purpose of the Study:

  • To compare the incidence of UTIs in pediatric patients across two distinct time periods.
  • To identify shifts in the prevalence of specific microbial pathogens and their resistance profiles.

Main Methods:

  • Retrospective analysis of UTI cases in pediatric patients (ambulatory and hospitalized).
  • Comparison of microbial isolates and their antimicrobial susceptibility between February 1999-March 2000 and April 2000-September 2001.
  • Identification of Gram-negative rods, Enterococcus spp., and Staphylococcus spp.

Main Results:

  • A notable increase in the frequency of extended-spectrum beta-lactamase (ESBL)-producing Gram-negative rods was observed in the second study period.
  • ESBL-producing strains exhibited co-resistance to aminoglycosides and trimethoprim/sulfamethoxazole.
  • Gram-negative rods were the predominant microorganisms causing UTIs. Enterococcus spp. were isolated in 20% of cases, with 9.4% being high-level aminoglycoside resistant (HLAR). No vancomycin-resistant Enterococcus spp. were found.
  • Methicillin-resistant coagulase-negative Staphylococci (MRCNS) accounted for 43.3% of CNS isolates.

Conclusions:

  • The study highlights an increasing trend of ESBL-producing Gram-negative rods in pediatric UTIs, indicating a growing challenge in treatment.
  • The prevalence of multidrug-resistant organisms necessitates vigilant monitoring and antimicrobial stewardship in pediatric hospitals.

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