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Related Experiment Videos

High-frequency switching in Candida albicans.

D R Soll1

  • 1Department of Biology, University of Iowa, Iowa City 52242.

Clinical Microbiology Reviews
|April 1, 1992
PubMed
Summary

Candida albicans exhibits reversible switching between cell phenotypes, impacting infection and adaptation. This study proposes an epigenetic mechanism for this Candida switching phenomenon.

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Area of Science:

  • Microbiology
  • Cell Biology
  • Genetics

Background:

  • Candida albicans, a common human pathogen, displays phenotypic switching.
  • Switching allows for reversible changes in colony morphology and cellular physiology.
  • This variability is superimposed on the standard yeast-to-hypha transition.

Purpose of the Study:

  • To investigate the phenomenon of phenotypic switching in Candida albicans.
  • To explore the impact of switching on cellular phenotypes, including the white-opaque transition.
  • To propose a molecular mechanism underlying the switching event.

Main Methods:

  • Characterization of different switching systems in Candida albicans strains.
  • Analysis of the white-opaque switching system and its associated cellular changes.
  • Review of recent approaches to elucidate the molecular mechanisms of switching.

Main Results:

  • Identified multiple switching systems in Candida albicans, each with a unique phenotype repertoire.
  • The white-opaque transition demonstrates significant alterations in antigen synthesis, gene expression, and cell wall structure.
  • Switching occurs in vivo during infection and recurrent vaginitis, suggesting an adaptive role.

Conclusions:

  • Phenotypic switching in Candida albicans generates adaptive variability in populations.
  • The white-opaque transition is a dramatic example of switching's effects on cell phenotype.
  • An epigenetic mechanism is proposed for the molecular basis of Candida albicans switching.

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