The widened frontal subarachnoid space. A CT comparative study between macrocephalic, microcephalic, and

J C Odita1

  • 1Department of Radiology, Hamad Medical Corporation, Doha, Qatar.

Insights

Frontal subarachnoid space widening in children is often not linked to macrocephaly. This finding suggests it may be a normal developmental variation, not necessarily external hydrocephalus.

Area of Science:

  • Pediatric Radiology
  • Neuroimaging
  • Developmental Pediatrics

Background:

  • Frontal subarachnoid space widening is a radiologic finding observed in pediatric computed tomographic (CT) scans.
  • This finding has been anecdotally associated with macrocephaly in children.

Purpose of the Study:

  • To retrospectively evaluate the association between frontal subarachnoid space widening and macrocephaly in pediatric patients.
  • To determine if clinical and radiologic characteristics differ between macrocephalic and normocephalic/microcephalic children with this finding.

Main Methods:

  • Retrospective review of CT head scans from 67 infants and children with frontal subarachnoid space widening over a 5-year period.
  • Analysis of patient cohorts based on head circumference (macrocephalic, normocephalic, microcephalic).
  • Comparison of clinical and radiologic features across these groups.

Main Results:

  • Macrocephaly was present in only 22.3% of the studied patients.
  • No significant differences were found in clinical or radiologic characteristics between macrocephalic and normocephalic/microcephalic children with frontal subarachnoid space widening.
  • The association between this radiologic sign and macrocephaly may be overemphasized.

Conclusions:

  • Frontal subarachnoid space widening in children might represent a normal developmental variation with transient cerebrospinal fluid accumulation.
  • The term "external hydrocephalus" may be inappropriate without significant ventricular enlargement or signs of increased intracranial pressure.
  • This finding warrants a re-evaluation of its diagnostic significance in the absence of other pathological indicators.

Related Concept Videos

Cranial Bones: Superior and Posterior View01:14

Cranial Bones: Superior and Posterior View

The superior view of the cranium shows the frontal and paired parietal bones.
The frontal bone is the single bone that forms the forehead. At its anterior midline, between the eyebrows, there is a slight depression called the glabella. The frontal bone also forms the supraorbital margin of the orbit. Near the middle of this margin is the supraorbital foramen, the opening that provides passage for a sensory nerve to the forehead. The frontal bone is thickened just above each supraorbital margin,...
Anatomy of the Brain: Ventricles01:18

Anatomy of the Brain: Ventricles

There are hollow fluid-filled cavities known as ventricles deep inside the human brain. There are two lateral ventricles, one in each cerebral hemisphere, and each has three different projections — the anterior, inferior, and posterior horns visible from the lateral side. A thin membrane called the septum pellucidum separates the two lateral ventricles. The slender third ventricle in the diencephalon is connected to each lateral ventricle via a channel called the interventricular foramen. The...
Increased Intracranial Pressure l: Introduction01:14

Increased Intracranial Pressure l: Introduction

Intracranial hypertension is a sustained elevation of intracranial pressure (ICP) above 22 mm Hg. In supine adults, normal ICP is ~7–15 mm Hg.The rigid, nonexpandable cranium contains three components—brain tissue, blood, and cerebrospinal fluid (CSF)—that total ~1,700 mL in a typical adult: 1,400 mL brain (~80%), 150 mL blood (~10%), and 150 mL CSF (~10%). According to the Monro–Kellie doctrine, total intracranial volume is effectively fixed. When one component expands, CSF and venous blood...
Increased Intracranial Pressure ll: Pathophysiology01:29

Increased Intracranial Pressure ll: Pathophysiology

Increased intracranial pressure (ICP) refers to a potentially life-threatening rise in pressure inside the skull. This usually happens when there is a major change in the volume of brain tissue, blood, or cerebrospinal fluid (CSF) — the three components inside the skull. According to the Monro-Kellie doctrine, if the volume of one component increases, the volumes of the other components must decrease to maintain normal pressure. If this does not happen, ICP rises.The process often begins with...