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Generation of Induced Regulatory T Cells from Primary Human Naïve and Memory T Cells
14:23

Generation of Induced Regulatory T Cells from Primary Human Naïve and Memory T Cells

Published on: April 16, 2012

The role of self-peptides in the development of CD4+ CD25+ regulatory T cells

Cristina Cozzo Picca1, Andrew J Caton

  • 1The Wistar Institute, 3601 Spruce Street, Philadelphia, PA 19104, USA.

Current Opinion in Immunology
|March 16, 2005
PubMed

The thymus produces a unique lineage of cells known as CD4+ CD25+ regulatory T cells, and the exact processes leading to their development continue to be defined. Highly specific interactions between developing thymocytes and cognate self-antigens expressed by radioresistant elements in the thymus have been shown to drive CD4+ CD25+ regulatory-T-cell development. The self-peptide(s) that mediate thymic selection of CD4+ CD25+ regulatory T cells can also promote their expansion in the periphery, and self-peptides might also play a role in the conversion of CD4+ CD25- T cells into CD25+ regulatory T cells.

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