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A novel homoisocarbacyclin analog with potent and long-lasting activity
M Shibasaki1, A Takahashi, T Aoki
1Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan.
Chemical & Pharmaceutical Bulletin
|January 1, 1992
Abstract:
A synthesis of a novel and chemically stable homoisocarbacyclin analog, TY-11223 (3), has been accomplished. The analog (3), given intravenously or orally, showed potent and long-lasting activities in inhibiting platelet aggregation and, in addition, a good selectivity in biological activities.