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Specificities of B cell reactions to drugs. The penicillin model
Miguel Blanca1, J A Cornejo-Garcia, M J Torres
1Allergy Service and Research Unit for Allergic Diseases, Carlos Haya Hospital, Plaza del Hospital Civil s/n, 29009 Malaga, Spain. miguel.blanca.sspa@juntadeandalucia.es
Abstract:
Betalactams conjugate to protein carriers induced T and B cell effector responses. From these, IgE dependent reactions are the most common and better defined. These antibodies recognize a number of structures that can cross react or selective recognition may occur. The great variability in the chemical structure, specifically at the position R of penicillin and R1 of cephallosporins has made that the recognition of these structures may have clinical relevance in the evaluation of patients allergic to betalactams.
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