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Updated: Aug 19, 2026

Primed Mycobacterial Uveitis (PMU) as a Model for Post-Infectious Uveitis
Published on: December 17, 2021
Conjunctival lymphoid hyperplasia presenting with bilateral panuveitis
Alexander S Ioannidis1, Poornima Rai, Bridget Mulholland
1Department of Ophthalmology, Royal Free Hospital, NHS Trust, London, United Kingdom. alexioannidis@hotmail.com
Purpose:
To report on a case of bilateral conjunctival lymphoid hyperplasia presenting with bilateral panuveitis in a female patient.
Design:
Observational case report.
Methods:
In this case excisional biopsy indicated lymphoid tissue. Immunohistochemistry showed a follicular architecture with appropriate zoning of B and T lymphocytes.
Results:
Causes of panuveitis were considered and excluded based on a detailed history, physical examination, and laboratory investigations. The bilateral panuveitis resolved on topical corticosteroids and visual acuity returned to normal.
Conclusions:
Ocular adnexal lymphoproliferative lesions consist of a spectrum of disease entities, including reactive lymphoid hyperplasia, atypical lymphoid hyperplasia, and lymphoma. There are no established clinical criteria to differentiate between these lesions. This case highlights the importance of a thorough ophthalmic examination in these patients, as an intra-ocular inflammatory process may accompany the conjunctival findings. Furthermore, we advocate periodic follow-up examinations because of the small potential risk of developing ocular or systemic lymphoma in these patients.
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