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High-grade and low-grade gliomas: differentiation by using perfusion MR imaging
B Hakyemez1, C Erdogan, I Ercan
1Department of Radiology, BURTOM Radioimaging Center, Bursa, Turkey. bahattinh@hotmail.com
Clinical Radiology
|March 16, 2005
Summary
Perfusion MRI using relative cerebral blood volume (rCBV) and relative cerebral blood flow (rCBF) effectively differentiates high-grade from low-grade gliomas. These perfusion parameters aid in preoperative assessment of glioma histopathological grade.
Area of Science:
- Neuroradiology
- Neuro-oncology
- Medical Imaging
Background:
- Relative cerebral blood volume (rCBV) is a standard perfusion MRI technique for tumor grading.
- Relative cerebral blood flow (rCBF) has been less extensively studied for this purpose.
Purpose of the Study:
- To evaluate the utility of rCBV and rCBF in assessing the histopathological grade of cerebral gliomas.
- To compare the effectiveness of rCBV and rCBF in differentiating glioma grades.
Main Methods:
- 33 patients with gliomas (22 high-grade, 11 low-grade) underwent perfusion MRI.
- rCBV and rCBF were calculated using deconvolution and normalized to contralateral white matter.
- Statistical analysis included Mann-Whitney testing, ROC analysis, and Pearson correlation.
Main Results:
- High-grade gliomas showed significantly higher rCBV (6.50) and rCBF (3.32) ratios than low-grade gliomas (rCBV 1.69, rCBF 1.16) (p < 0.001).
- ROC analysis indicated cut-off values of 1.98 for rCBV and 1.25 for rCBF for grade discrimination.
- A strong positive correlation (r=0.830, p<0.05) was observed between rCBV and rCBF ratios.
Conclusions:
- Perfusion MRI, incorporating both rCBV and rCBF, is valuable for preoperative grading of gliomas.
- rCBF offers complementary information to rCBV in the MR perfusion analysis for glioma evaluation.