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Photoablative inlay laser in situ keratomileusis (PAI-LASIK) in the rabbit model
Gholam A Peyman1, Craig F Beyer, Yanno Bezerra
1Department of Ophthalmology, Tulane University Health Sciences Center, New Orleans, Louisiana 70112-2699, USA.
Purpose:
To evaluate the suitability, biocompatibility, and efficacy of a proprietary hydrogel photoablative inlay (PAI) for use during laser in situ keratomileusis (LASIK).
Setting:
Laboratory study, Tulane University Health Sciences Center, New Orleans, Louisiana, USA.
Methods:
Eight rabbits (1 eye each) underwent the PAI-LASIK procedure; 4 eyes had a disk-shaped inlay and 4, a donut-shaped inlay. Preoperatively, the hydrogel material was ablated with a programmed correction of 5.0 diopters of hyperopia or myopia.
Results:
The eyes were followed for 1 to 16 months. No eye showed signs of rejection or extrusion of the PAI. There was no significant difference in corneal clarity or the healing rate between eyes with donut-shaped PAIs and those with disk-shaped PAIs. One eye with a donut-shaped PAI had minimal corneal haze. The remaining inlays did not opacify or fracture during ablation.
Conclusion:
The hydrogel material can be used for the proposed PAI-LASIK procedure.
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