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Right ventricular function at rest and during exercise in chronic obstructive pulmonary disease.

R A Matthay1, A C Arroliga, H P Wiedemann

  • 1Yale University School of Medicine, New Haven, Conn.

Chest
|May 1, 1992
PubMed
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Right ventricular ejection fraction (RVEF) is often reduced in chronic obstructive pulmonary disease (COPD) due to increased pulmonary pressures. Therapies targeting this afterload may improve RVEF, but only oxygen improves survival in COPD patients.

Area of Science:

  • Cardiology
  • Pulmonology
  • Medical Physiology

Background:

  • Right ventricular ejection fraction (RVEF) assesses the right ventricle's systolic function.
  • Reduced RVEF is common in chronic obstructive pulmonary disease (COPD), both at rest and during exercise.
  • Increased pulmonary artery pressure and vascular resistance (right ventricular afterload) are primary causes of reduced RVEF in COPD.

Purpose of the Study:

  • To explore therapeutic strategies for improving RVEF in COPD patients.
  • To evaluate agents that reduce right ventricular afterload.
  • To determine the impact of these therapies on RVEF and survival.

Main Methods:

  • Review of existing literature on RVEF in COPD.
  • Analysis of the effects of various pharmacological agents on RVEF.

Related Experiment Videos

  • Assessment of survival data related to RVEF-improving therapies.

    • Main Results:

    • Several agents, including oxygen, vasodilators, theophylline, and sympathomimetics, can improve RVEF.
    • These improvements are often linked to reductions in pulmonary vascular resistance and pulmonary artery pressure.
    • Only oxygen therapy has demonstrated an improvement in survival rates.

    Conclusions:

    • Therapeutic interventions targeting right ventricular afterload hold potential for improving RVEF in COPD.
    • Oxygen therapy is the only intervention discussed that improves survival in COPD patients with reduced RVEF.
    • Further research may be needed to optimize treatments for right ventricular dysfunction in COPD.