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Clinical results of Perftoran application: present and future
Eugene Maevsky1, Genrih Ivanitsky, Ludmila Bogdanova
1Institute of Theoretical and Experimental Biophysics of RAS, Moscow Region, Russia. emaevsky@iteb.ru
Summary
Perftoran, a perfluorochemical emulsion, enhances oxygen delivery and shows potential beyond blood substitution. Clinical studies indicate its efficacy in treating vascular diseases, improving surgical outcomes, and accelerating wound healing.
Area of Science:
- Biomedical Engineering
- Pharmacology
- Regenerative Medicine
Background:
- Perftoran is a low-concentration perfluorochemical emulsion used clinically.
- Russian scientific literature details its applications and clinical trials.
Purpose of the Study:
- To review clinical experience and data on Perftoran applications.
- To explore Perftoran's potential beyond its role as a blood substitute.
Main Methods:
- Analysis of statistical data from clinical trials.
- Review of Russian scientific literature on Perftoran applications.
Main Results:
- Perftoran facilitates oxygen delivery alongside red blood cells during blood replacement.
- Infusion alleviates ischemia in occlusive vascular disease.
- Improves outcomes in plastic surgery grafting, reduces inflammation, and prevents transplant rejection.
- Activates liver detoxification and inhibits retrovirus infection.
- Local application accelerates wound and ulcer healing.
Conclusions:
- Perftoran demonstrates a wide therapeutic potential beyond blood substitution.
- Further applications in treating vascular conditions, surgical recovery, and infectious diseases are suggested.