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EAMI--exercise training in anterior myocardial infarction: an ongoing multicenter randomized study. Preliminary
P Giannuzzi1, P L Temporelli, L Tavazzi
1Centro Medico di Riabilitazione, Veruno, Italy.
Chest
|May 1, 1992
Summary
A 6-month exercise program improved work capacity in myocardial infarction patients but did not prevent left ventricular (LV) deterioration in those with reduced ejection fraction (EF). Physical training did not alter the natural decline in LV function for this vulnerable group.
Area of Science:
- Cardiology
- Exercise Physiology
- Cardiac Rehabilitation
Background:
- Myocardial infarction (MI) can lead to left ventricular (LV) dysfunction and remodeling.
- Early assessment of LV function is crucial for prognosis after MI.
- Exercise training is a common component of cardiac rehabilitation.
Purpose of the Study:
- To evaluate the impact of a 6-month exercise training program on LV function and remodeling in patients post-MI.
- To assess if exercise training can mitigate adverse LV changes in patients with reduced ejection fraction (EF).
Main Methods:
- 49 patients with first Q anterior MI were randomized into training (T) or control (C) groups.
- 2D-echocardiography and bicycle ergometry assessed LV function, volumes, EF, and wall motion abnormalities.
- Measurements were taken at baseline (4-8 weeks post-MI) and 6 months later.
Main Results:
- The training group showed significant improvements in work capacity and lactic anaerobic threshold.
- No significant changes in LV volumes, EF, or remodeling were observed in either group.
- Patients with EF < 40% exhibited progressive LV dilation and wall motion deterioration, irrespective of training.
Conclusions:
- Exercise training enhances functional capacity post-MI.
- Patients with reduced EF (<40%) are prone to further LV deterioration, which is not prevented by this exercise program.
- Physical training does not appear to exacerbate spontaneous LV deterioration in this high-risk group.