Related Experiment Video
Updated: Aug 19, 2026
A Protocol to Acquire the Degenerative Tenocyte from Humans
Published on: June 9, 2018
Giant cell tumor of tendon sheath arising in the toe
Elise Occhipinti1, Stephen D Heinrich, Randall Craver
1Department of Pathology, Louisiana State Uiversity Health Sciences Center, New Orland, Louisiana, USA.
Insights
Giant cell tumors of the tendon sheath are rare in children but share features with adult cases. This study highlights lower extremity involvement in pediatric patients with these benign soft tissue tumors.
Area of Science:
- Orthopedics
- Pediatric Oncology
- Skeletal System Neoplasms
Background:
- Giant cell tumor of the tendon sheath (GCTTS), also known as nodular tenosynovial giant cell tumor, is a common benign soft tissue tumor.
- GCTTS typically affects middle-aged women and most frequently occurs in the interphalangeal joints of the fingers.
Observation:
- This report details two pediatric cases of GCTTS affecting the toes in a 12-year-old boy and a 6-year-old girl.
- The tumor in the 12-year-old boy exhibited the characteristic cytogenetic translocation t(1;2)(p13;q37), previously identified in adult GCTTS.
Findings:
- Pediatric GCTTS cases demonstrate histological and cytogenetic similarities to adult GCTTS.
- A potential predilection for lower extremity involvement in pediatric GCTTS is suggested by these cases.
Implications:
- These findings expand the understanding of GCTTS occurrence in pediatric populations.
- Recognizing lower extremity GCTTS in children is crucial for accurate diagnosis and management, despite its rarity.
Abstract:
Giant cell tumor of the tendon sheath (nodular synovitis) is a benign soft tissue tumor, usually affecting older women, that most often occurs in the interphalangeal joints of the fingers. Occurrence is rare in children. We present a 12-year-old boy and a 6-year-old girl with giant cell tumors of tendon sheaths occurring in the toes. The tumor from the 12-year-old demonstrated the cytogenetic finding of t(1;2)(p13;q37), which previously has been associated with giant cell tumor of tendon sheath in adults. Giant cell tumors of the tendon sheath occurring in children have similar histological and cytogenetic features as adults, however, there may be a predilection for lower extremity involvement.
Related Concept Videos
01:28Muscles of the Leg that Move the Foot and Toes
Anterior Compartment
The anterior compartment includes muscles that contribute to the dorsiflexion of the foot. This compartment houses the tibialis anterior, extensor hallucis longus, and extensor digitorum longus muscles.
01:10Ankle Joint