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[Clinical observation of the lead discharging effect of paiqian chewing tablet]
Jian-zhong Lu1, Yu Cai, Yi-bin Lu
1Center of Technology, Jiangzhong Pharmaceutical Co. Ltd., Nanchang 330077.
Insights
Paiqian chewing tablet (PQCT) effectively enhances lead excretion in children without impacting essential mineral levels. This study confirms PQCT
Area of Science:
- Environmental Health
- Pediatric Toxicology
- Pharmacology
Background:
- Lead exposure in children poses significant health risks.
- Elevated blood lead levels necessitate effective interventions for lead detoxification.
- Current treatments for lead poisoning require careful consideration of efficacy and safety.
Purpose of the Study:
- To evaluate the efficacy of paiqian chewing tablet (PQCT) in promoting lead excretion in children.
- To assess the safety profile of PQCT regarding essential mineral balance and overall health.
- To determine if PQCT can safely reduce elevated blood lead levels.
Main Methods:
- A randomized controlled trial involving 94 children with blood lead levels >100 microg/L.
- Comparison between an observed group receiving PQCT and a control group over a 30-day period.
- Monitoring of urinary lead output, and routine blood and urine indexes.
Main Results:
- Significantly increased urinary lead output in the PQCT group compared to the control group at days 20 and 30 (P < 0.05, P < 0.01).
- PQCT demonstrated a marked improvement in total urinary lead excretion (P < 0.05).
- No adverse effects on urinary calcium and zinc excretion were observed.
Conclusions:
- Paiqian chewing tablet (PQCT) is effective in enhancing lead discharging in children.
- PQCT shows a favorable safety profile, with no negative impact on essential mineral excretion.
- The study indicates that PQCT is harmless for children with elevated lead levels.
Objective:
To observe the effect of paiqian chewing tablet (PQCT) on lead discharging and health in children.
Methods:
Adopting self-control and inter-group control method, 94 children with blood lead level exceeding 100 microg/L were randomly divided into the observed group and the control group. The observation period for both groups was 30 days.
Results:
At the 20th and 30th day of treatment, the urinary lead output in the observed group was significantly higher than that in the control group (P < 0.05, P < 0.01), and showed significant difference as compared with that before treatment (P < 0.05). Besides, the total amount of urinary lead discharging in the observed group was significantly more than that in the control group (P < 0.05).
Conclusion:
PQCT has markedly lead discharging improvement action with no influence on urinary calcium and zinc excretion. As all the routine indexes of blood and urine ranged within the normal extent, it demonstrated that PQCT was harmless to the health of observed individual.
