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Updated: Aug 19, 2026
Estrogen-Like Effect of Bazi Bushen Capsule in Ovariectomized Rats
Published on: April 7, 2023
[Study on the differentially expressed genes in bone tissue of ovariectomized rats after intervention with Chinese
Yu-ying Ma1, Xin-min Zhang, Shi-feng Li
1Institute of Integrated Chinese and Western Medicine, Huashan Hospital, Fudan University, Shanghai 200040.
Objective:
To explore the therapeutic effect and mechanism of jiangu granule (JGG) on postmenopausal osteoporosis.
Methods:
Differential display reverse transcription PCR (DDRT-PCR) was used to detect the differentially expressed genes in bone tissues associated with therapeutic effect of JGG.
Results:
Ten differentially expressed gene fragments were found, 9 of them, after cloning, sequencing and BLAST searching, were proved to be matched with highly homologous sequences in Genebank. Among them, two were known proteins: hyaluronan-mediated motility receptor (RHAMM) and ATPase, Na+, K+ transporting beta 3 polypeptide (ATP1b3). It was confirmed by semi-quantitative RT-PCR that these two gene fragments could be down- and up-regulated by JGG respectively.
Conclusion:
The therapeutic effect of JGG in treating postmenopausal osteoporosis might be related with its regulation on the two kinds of protein, RHAMM and ATP1b3.
