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Updated: Aug 7, 2026
14:53
Intra-Arterial Delivery of Neural Stem Cells to the Rat and Mouse Brain: Application to Cerebral Ischemia
Published on: June 26, 2020
The role of cell therapy for stroke
Douglas Kondziolka1, Lawrence Wechsler, Elizabeth Tyler-Kabara
1Department of Neurological Surgery, University of Pittsburgh, Pennsylvania, USA. kondziol@neuronet.pitt.edu
Neurosurgical Focus
|March 17, 2005
Summary
Cellular therapy shows promise for repairing brain injury after stroke. Early human clinical trials are now underway for motor-related stroke patients, using neuronal transplantation.
Area of Science:
- Neuroscience
- Regenerative Medicine
- Clinical Neurology
Background:
- Cellular therapy is being explored for brain injury repair.
- Stroke models in animals and primates have been used for evaluation.
- Neuronal transplantation is a key area of investigation.
Purpose of the Study:
- To describe the current state of cellular therapy for stroke-related brain injury.
- To report on early clinical trials in human patients.
- To highlight the use of experimental striate stroke models.
Main Methods:
- Evaluation of cellular therapy in animal models (small animals, primates).
- Development of experimental striate stroke models.
- Initiation of early clinical trials for human patients.
Main Results:
- Cellular therapy has been tested in preclinical models.
- Experimental stroke models are effective for evaluating treatments.
- Early clinical trials for stroke patients have commenced.
Conclusions:
- Cellular therapy holds potential for stroke repair.
- Preclinical research supports clinical translation.
- Ongoing trials will provide crucial data on efficacy and safety.
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