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Related Concept Videos

Toxidromes: Clinical Features01:30

Toxidromes: Clinical Features

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Toxidromes are specific patterns of symptoms resulting from toxic substance exposure. They help in the identification and treatment of poisoning. The symptoms of each toxidrome group indicate poisoning by a certain class of chemicals or drugs.1. Sympathomimetic: Stimulates the sympathetic nervous system. Symptoms include agitation, increased heart rate (HR), blood pressure (BP), respiratory rate (RR), temperature, and pupil size. Drugs like cocaine and amphetamines, along with tremors and...
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Pericarditis is distinguished by inflammation of the pericardium, the fibrous sac that encases the heart. It can be acute, lasting less than six weeks, or chronic, persisting for over three months. Understanding its clinical manifestations and diagnostic findings is crucial for timely and effective management.Clinical ManifestationsWhile pericarditis can be asymptomatic, it usually presents with characteristic symptoms such as:Chest Pain: The most characteristic symptom of pericarditis is chest...
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Endocarditis II: Clinical Features of Infective Endocarditis01:25

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Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...
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Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
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The adaptive immune system, a crucial component of the overall immune response, offers a highly specialized defense against pathogens. It involves specific cell types and features, enabling it to combat infections effectively and efficiently.
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Patients with esophageal strictures often experience a range of symptoms. Initially, they may have difficulty swallowing solid foods, which can progress to include liquids. Additional symptoms may involve chest pain or discomfort, regurgitating food and fluids, heartburn, unintentional weight loss, coughing or choking during meals, and hoarseness.
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Related Experiment Video

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DIPLOMA Approach for Standardized Pathology Assessment of Distal Pancreatectomy Specimens
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Pathological features of NASH.

Elizabeth M Brunt1, Dina G Tiniakos

  • 1Department of Pathology, Saint Louis University School of Medicine, St. Louis, MO, USA. bruntem@slu.edu <bruntem@slu.edu>

Frontiers in Bioscience : a Journal and Virtual Library
|March 17, 2005
PubMed
Summary

Nonalcoholic fatty liver disease (NAFLD) involves liver fat accumulation, ranging from simple steatosis to steatohepatitis with fibrosis. This review covers its histopathology, history, and significance in adults and children.

Area of Science:

  • Hepatology
  • Gastroenterology
  • Pathology

Background:

  • Nonalcoholic fatty liver disease (NAFLD) is characterized by hepatic triglyceride accumulation, microscopically identified as macrovesicular steatosis.
  • NAFLD encompasses a spectrum of liver injury, from simple steatosis to steatohepatitis, potentially with fibrosis.

Purpose of the Study:

  • To provide a comprehensive overview of the histopathologic spectrum of NAFLD.
  • To include a historical perspective and current understanding of NAFLD's significance.
  • To summarize findings on pediatric NAFLD alongside adult cases.

Main Methods:

  • Histopathologic review of NAFLD.
  • Literature synthesis for historical context and contemporary significance.
  • Compilation of pediatric NAFLD data.

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Main Results:

  • Detailed discussion of the histopathologic features defining NAFLD.
  • Exploration of the evolution of understanding NAFLD.
  • Summary of current knowledge on NAFLD in both adult and pediatric populations.

Conclusions:

  • NAFLD represents a broad histopathologic entity with significant clinical implications.
  • Understanding the full spectrum and historical context is crucial for managing NAFLD.
  • NAFLD is increasingly recognized in pediatric populations, necessitating further research.