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Nutraceuticals and cancer management.
Yamini B Tripathi1, Pratibha Tripathi, Behram H Arjmandi
1Department of Medicinal Chemistry, Institute of Medical Sciences, Banaras Hindu University, Varanasi-221005, India. yaminiok@yahoo.com <yaminiok@yahoo.com>
Frontiers in Bioscience : a Journal and Virtual Library
|March 17, 2005
Summary
Complementary and alternative medicine (CAM), including Ayurvedic herbal remedies, shows promise in cancer prevention by inhibiting cell proliferation. These natural compounds are explored by cancer patients seeking alternatives to conventional treatments.
Area of Science:
- Integrative Oncology
- Phytomedicine Research
- Nutritional Science
Background:
- Complementary and alternative medicine (CAM) use is rising globally, with traditional systems like Ayurveda gaining attention.
- Plant-derived products are widely used as herbal medicines, food supplements, and culinary spices.
- Cancer patients increasingly seek CAM due to the side effects and risks of conventional treatments.
Purpose of the Study:
- To review phytomedicines from Indian and European traditional systems with demonstrated anti-cancer effects.
- To explore the role of vitamins, minerals, and dietary fats in cancer prevention and control.
- To discuss the mechanisms of action of these phytomolecules.
Main Methods:
- Literature review of experimental (in vivo and in vitro) cancer models.
- Analysis of studies on phytomedicines, vitamins, minerals, and dietary fats.
- Examination of clinical trial data and available food supplements.
Main Results:
- Several plant-derived compounds show significant inhibition of cancer cell proliferation in experimental models.
- Some phytomedicines are progressing through clinical trials or are available as supplements.
- Vitamins, minerals, and dietary fat composition play a role in cancer control.
Conclusions:
- Phytomedicines, particularly from the Indian system of medicine, offer potential in cancer progression prevention.
- Understanding the mechanisms of action of these natural compounds is crucial for their therapeutic application.
- CAM, including dietary factors, represents a valuable area for adjunct cancer management strategies.