Acid mucopolysaccharides of congenitally defective, rheumatic, and normal human aortic valves

The qualitative nature, total amount, and relative proportion of various acid mucopolysaccharides (AMPSs) found in congenitally defective (bicuspid), young rheumatic, and normal aortic valvular tissue were compared. No differences in the qualitative nature of AMPSs were found in any of the aortic tissues studies; hyaluronic acid, chondroitin sulfate B, and chondroitin sulfate A/C were the primary AMPS components, with a trace amount of heparin. Congenitally defective aortic valves showed increasing amounts of calcification, a lowering of total AMPS content, and an alteration in the relative proportions of various AMPS with advancing age, as compared with age-matched normal aortic valves. The total AMPS content of rheumatic aortic valves from individuals under the age of 21 years was found to be significantly higher than that of age-matched normal controls. In addition, these rheumatic aortic valves showed an alteration in AMPS composition that was similar to that of congenitally defective aortic valves obtained from older individuals. These observations suggest nonspecific changes in the AMPS composition caused by chronic tissue damage, calcification, and fibrosis.