Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Biliary atresia.

Mark Davenport1

  • 1Department of Paediatric Surgery, Kings College Hospital, London, UK. Markdav2@ntlworld.com

Seminars in Pediatric Surgery
|March 17, 2005
PubMed
Summary
This summary is machine-generated.

Biliary atresia (BA) is a serious infant liver disease with unknown causes. Early surgery offers over 50% of infants a good chance of survival and improved quality of life.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Preface to topic collection: biliary atresia.

World journal of pediatric surgery·2026
Same author

Quality of care received by children with suspected appendicitis in the UK National Health Service.

Anaesthesia·2026
Same author

Pediatric cholecystectomy practices and training: an International Multicenter Survey by the European Union of Medical Specialists (UEMS) Section of Paediatric Surgery.

Pediatric surgery international·2026
Same author

Type 1 Congenital Pulmonary Airway Malformation: Diagnostic Accuracy of Radiological Features.

Pediatric pulmonology·2026
Same author

Serum aspartate aminotransferase to platelet ratio index in relation to liver histopathology of biliary atresia.

Journal of pediatric gastroenterology and nutrition·2026
Same author

Generative AI and medical writing: Malfeasance or misdemeanour?

Journal of pediatric surgery·2026
Same journal

The EXTra-uterine Environment for Neonatal Development (EXTEND) - future treatment for prematurity and potentially other congenital disease.

Seminars in pediatric surgery·2026
Same journal

Appendicitis as a model for pediatric surgical quality improvement and standardization.

Seminars in pediatric surgery·2026
Same journal

From FOB to PICU: military trauma systems that changed pediatrics.

Seminars in pediatric surgery·2026
Same journal

Long-term follow-up after surgery for congenital anomalies: A time to complication analysis.

Seminars in pediatric surgery·2026
Same journal

Radio-surgical decision-making in hepatoblastoma in the post-PHITT era: SIOPEL consensus recommendations.

Seminars in pediatric surgery·2026
Same journal

Seminars in pediatric sugery pediatric metabolic and bariatric surgery.

Seminars in pediatric surgery·2026
See all related articles

Area of Science:

  • Pediatric Hepatology
  • Infant Liver Disease
  • Biliary Atresia Research

Background:

  • Biliary atresia (BA) is a severe infant liver condition with largely unknown origins.
  • Hypotheses include abnormal bile duct development, viral infections, immune responses, and bile acid issues.
  • Current understanding of BA's inflammatory components is limited, especially regarding the interaction of various factors.

Purpose of the Study:

  • To review the current understanding of biliary atresia (BA) etiology and management.
  • To highlight the need for further research into the complex interactions of factors contributing to BA.
  • To outline the clinical management strategies for infants diagnosed with BA.

Main Methods:

  • Review of existing literature on biliary atresia.

Related Experiment Videos

  • Analysis of recent studies utilizing molecular biology and immunohistochemistry.
  • Synthesis of clinical outcomes data for BA management.

    • Main Results:

    • While molecular techniques have advanced understanding of BA's inflammation, the interplay of causative factors remains unclear.
    • The Kasai procedure (portoenterostomy) is the primary surgical intervention for restoring bile flow and reducing jaundice.
    • Over 50% of infants treated in major centers achieve jaundice clearance and long-term survival with good quality of life.

    Conclusions:

    • Biliary atresia (BA) management relies on early portoenterostomy to improve outcomes.
    • Liver transplantation is reserved for cases with advanced chronic liver disease.
    • Successful jaundice clearance post-Kasai procedure indicates a positive prognosis for many infants with BA.