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CNS recurrence following CD34+ peripheral blood stem cell transplantation in stage 4 neuroblastoma
Hyoung Soo Choi1, Sang Hyeok Koh, Eun Sil Park
1Department of Pediatrics and Cancer Research Institute, Seoul National University College of Medicine, Seoul 110-744, Korea.
Abstract:
We report here central nervous system (CNS) recurrence in neuroblastoma (NBL) after CD34(+) peripheral blood stem cell transplantation (PBSCT). Fifteen stage 4 NBL patients underwent CD34(+) transplantation with myeloablative chemotherapy consisting of carboplatin, etoposide, and melphalan. There were three primary site recurrences and five distant metastases including four brain metastases (two isolated CNS recurrences) at 4-7 months after CD34(+) transplantation. Three of four patients died of CNS progressive disease at 2, 8, and 9 months after recurrence and the remaining single patient was lost to follow-up. CNS recurrence in NBL is fatal and requires identification of risk factors and more effective treatment strategies.
