Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Basic fibroblast growth factor in leiomyoma].

Małgorzata Wolańska1, Krzysztof Sobolewski

  • 1Zakład Biochemii Lekarskiej Akademii Medycznej w Białymstoku.

Polski Merkuriusz Lekarski : Organ Polskiego Towarzystwa Lekarskiego
|March 18, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Grade-dependent changes in sphingolipid metabolism in clear cell renal cell carcinoma.

Journal of cellular biochemistry·2022
Same author

Enhanced Expression but Decreased Specific Activity of Matrix Metalloproteinase 10 (MMP-10) in Comparison with Matrix Metalloproteinase 3 (MMP-3) in Human Urinary Bladder Carcinoma.

Journal of clinical medicine·2021
Same author

Peptide growth factors and their receptors in the vein wall.

Journal of investigative medicine : the official publication of the American Federation for Clinical Research·2019
Same author

MT1-MMP evaluation in neointimal hyperplasia in the late follow-up after prosthesis implantation.

International journal of experimental pathology·2019
Same author

A New Analytical Method for Determination of Cathepsin L Based on the Surface Plasmon Resonance Imaging Biosensor.

International journal of molecular sciences·2019
Same author

Divergent changes in the content and activity of MMP-26 and TIMP-4 in human umbilical cord tissues associated with preeclampsia.

European journal of obstetrics, gynecology, and reproductive biology·2018

Basic fibroblast growth factor (bFGF) binds to leiomyoma tissues, with higher levels in larger tumors. This suggests bFGF may indicate tumor growth intensity in leiomyoma.

Area of Science:

  • Biochemistry
  • Cell Biology
  • Oncology

Context:

  • Fibroblast growth factor (FGF) stimulates extracellular matrix (ECM) biosynthesis.
  • Heparan sulfate, a major proteoglycan in leiomyoma ECM, binds FGF.
  • The role of bFGF in leiomyoma development is not fully understood.

Purpose:

  • To investigate the presence and binding of basic fibroblast growth factor (bFGF) in human leiomyoma tissues.

Summary:

  • Basic fibroblast growth factor (bFGF) was detected and found to bind to various molecular weight components within leiomyoma tissue.
  • The majority of bFGF was identified in larger leiomyoma samples.
  • bFGF binding appears to correlate with tissue components, suggesting a role in ECM remodeling.

Related Experiment Videos

Impact:

  • The study suggests that bFGF levels in leiomyoma may serve as a biomarker for tumor growth intensity.
  • Findings contribute to understanding the role of growth factors in uterine leiomyoma pathogenesis.
  • This research may inform future therapeutic strategies targeting bFGF signaling in leiomyomas.