[Effect of exercise on chosen parameters of endothelium function in middle age health humans]

Physical effort is possible to perform by increasing blood flow in working muscles. The endothelial cells produce vasoactive factors that regulate vessel wall tension, among others endothelin 1 (ET1) a potent vasoconstrictor and adrenomedullin (AD1)--vasodilatatory peptide. It was investigated in volunteers whether the ET-1 and ADM concentration in plasma changes by exercise. Bicycle exercise test was performed in 28 healthy persons. There were used standard RIA kits to measure ADM and ELISA method to determine ET-1 concentration in plasma. Average ET-1 and ADM levels in plasma were different before and after the exercise, the standard exercise test significantly decrease ET-1 and ADM concentration in plasma. The investigation indicates that with the decrease of the vessel resistance under the physical exercise the concentration of ET-1 obtains lower level. The lack of stimulating ET-1 influence on secretion of ADM can be the effect of the decrease of ADM concentration.