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Updated: Aug 19, 2026

Probiotic Studies in Neonatal Mice Using Gavage
Published on: January 27, 2019
Immunoenhancing effects of a new probiotic strain, Lactobacillus fermentum PL9005
Jong-Hwan Park1, Yeonhee Lee, Enpyo Moon
1Department of Laboratory Animal Medicine, College of Veterinary Medicine and School of Agricultural Biotechnology, Seoul National University, Seoul 151-742, Korea.
Abstract:
The immunoenhancing effects of Lactobacillus fermentum PL9005 were assessed via mouse intragastric inoculation. The number of immunoglobulin A-positive cells in the small intestine, CD4+ T lymphocytes in the peripheral blood, and the lymphocyte proliferation response to mitogen stimulation (lipopolysaccharide) increased in mice fed L. fermentum PL9005. The lactic acid concentration also increased dose dependently in the small intestine of mice fed L. fermentum PL9005. No differences were found in body weight, food intake, and clinical signs between mice fed L. fermentum PL9005 and the control group. Results indicated that L. fermentum PL9005 is a probiotic with immunoenhancing properties.
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