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Pulse-Wave Velocity, Flow-Mediated Dilation, and Carotid Intima-Media Thickness to Assess Cardiovascular Risk in Population with Metabolic Syndrome
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Aortic pulse wave velocity as an independent marker of coronary artery disease

Hong Euy Lim1, Chang Gyu Park, Sung Hee Shin

  • 1Division of Cardiology, Cardiovascular Center, Korea University Hospital, Guro-Dong, Guro-Gu, Seoul KR-152-050, Korea.

Blood Pressure
|March 18, 2005
PubMed

Insights

Pulse wave velocity (PWV) is an independent risk marker for coronary artery disease (CAD) and its severity. Higher PWV in patients with CAD indicates increased cardiovascular risk.

Area of Science:

  • Cardiology
  • Vascular Medicine

Background:

  • Arterial stiffness is a significant contributor to cardiovascular morbidity and mortality in hypertensive patients.
  • Pulse wave velocity (PWV) measures large artery damage but its independent role in coronary artery disease (CAD) requires further investigation.

Purpose of the Study:

  • To determine if PWV is associated with cardiovascular risk.
  • To assess PWV as an independent risk factor for CAD.

Main Methods:

  • Prospective enrollment of 326 patients undergoing coronary angiography for suspected CAD.
  • Aorto-femoral PWV assessed using a fluid-filled system.
  • Multivariate logistic regression analysis including age, diabetes, and other CV risk factors.

Main Results:

  • PWV was significantly higher in patients with CAD compared to those without (12.5 +/- 5.1 vs 10.2 +/- 3.1 m/s, p < 0.001).
  • PWV remained a significant independent predictor of CAD (p = 0.050) after adjusting for other risk factors.
  • PWV showed a significant association with the severity of CAD (p < 0.001).

Conclusions:

  • PWV is an independent risk marker for CAD.
  • PWV is strongly associated with the severity of CAD, highlighting its clinical relevance.
Abstract

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