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Absence of hypercoagulability in acute Kawasaki disease

Ming-Tsan Lin1, Lon-Yen Tsao, Ming-Lin Cheng

  • 1Department of Pediatrics, Changhua Christian Hospital, Changhua 500, Taiwan. mtsy@ms18.hinet.net

Pediatrics International : Official Journal of the Japan Pediatric Society
|March 18, 2005
PubMed

Insights

This study found no evidence of hypercoagulability in acute Kawasaki disease (KD). Biomarkers of endothelial cell activation and clotting are not predictive of coronary aneurysms in KD patients.

Area of Science:

  • Cardiovascular Research
  • Pediatric Rheumatology
  • Hematology

Background:

  • Kawasaki disease (KD) is a vasculitis affecting children, often leading to cardiovascular complications.
  • Endothelial cell (EC) damage is implicated in KD pathogenesis and coronary vascular disorders.
  • Prethrombotic complications may arise from EC activation in KD.

Purpose of the Study:

  • To investigate the role of EC activation and hypercoagulability in KD.
  • To determine if plasma markers correlate with coronary aneurysm development in KD.

Main Methods:

  • Assessed EC function and coagulation in 52 acute KD patients and 20 controls.
  • Measured markers: thrombomodulin, tissue factor, tissue factor pathway inhibitor, von Willebrand factor (vWF), coagulation factor VII (FVII), activated FVII, prothrombin fragment 1 + 2 (F1 + 2), and D-dimer.

Main Results:

  • Coronary artery dilatation occurred in 55.8%, aneurysms in 9.6% of KD patients.
  • Elevated vWF, FVII, F1 + 2, and D-dimer in KD vs. healthy controls, but not febrile controls.
  • No significant differences in EC/hypercoagulability markers between patients with/without cardiac complications.

Conclusions:

  • Hypercoagulability is not evident during the acute phase of Kawasaki disease.
  • EC damage and hypercoagulability markers do not predict coronary aneurysms in KD.
Abstract

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