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Updated: Aug 19, 2026

Defining Gene Functions in Tumorigenesis by Ex vivo Ablation of Floxed Alleles in Malignant Peripheral Nerve Sheath Tumor Cells
Published on: August 25, 2021
A clonal reciprocal t(2;7)(p13;p13) in plantar fibromatosis
Jeffrey R Sawyer1, Gael Sammartino, Neriman Gokden
1Department of Pathology, Cytogenetics Laboratory, University of Arkansas for Medical Sciences, Freeway Medical, Suite 200, 5800 West 10th Street, Little Rock, AR 72204, USA. sawyerjeffreyr@uams.edu
Abstract:
Cytogenetic reports of plantar fibromatosis are rare, and to our knowledge no clonal reciprocal translocations have been reported in these lesions. Reciprocal chromosome translocations have been identified in a number of solid tumors and in some cases have helped identify genes involved in their pathogenesis. We report a case of plantar fibromatosis with the novel finding of a t(2;7)(p13;p13) balanced reciprocal translocation as the sole cytogenetic abnormality.
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