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Published on: April 1, 2019

[Association of plasma homocysteine and cystathionine beta-synthase polymorphism with cerebral thrombosis]

Yan Shao1, Cheng-Guo Zhang, Jin-Huan Cui

  • 1Department of Neurology, First People's Hospital of Foshan City, Foshan 528000, China. shaoyan2001@21cn.com

Di 1 Jun Yi Da Xue Xue Bao = Academic Journal of the First Medical College of PLA
|March 18, 2005
PubMed

Insights

Elevated plasma homocysteine (Hcy) levels are linked to a higher risk of cerebral thrombosis. While common cystathionine beta-synthase (CBS) mutations don't show a direct association, hyperhomocysteinemia itself is a significant risk factor.

Area of Science:

  • Biochemistry
  • Genetics
  • Neurology

Context:

  • Cerebral thrombosis is a significant cause of stroke.
  • Elevated plasma homocysteine (Hcy) is a potential risk factor.
  • Cystathionine beta-synthase (CBS) gene polymorphism may influence Hcy levels.

Purpose:

  • To investigate the association between plasma Hcy levels, CBS gene polymorphism, and cerebral thrombosis.
  • To determine if specific CBS mutations are linked to an increased risk of cerebral thrombosis.

Summary:

  • Patients with cerebral thrombosis exhibited significantly higher fasting plasma Hcy levels compared to controls.
  • Plasma Hcy levels demonstrated variation across different CBS genotypes.
  • No significant differences in CBS genotype or allele frequencies were observed between patient and control groups.

Impact:

  • Hyperhomocysteinemia, rather than common CBS mutations, is directly associated with an increased risk of cerebral thrombosis.
  • Findings suggest that monitoring and managing Hcy levels may be crucial for preventing cerebral thrombosis.
Abstract

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