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Vigorous exercise acutely changes platelet and B-lymphocyte CD39 expression.

Antonino Coppola1, Ludovico Coppola, Liliana dalla Mora

  • 1Divisione di Astanteria Medica e Geriatria, Policlinico Universitario, Piazza Miraglia 2, 80138 Napoli, Italy. ludovico.coppola@unina2.it

Journal of Applied Physiology (Bethesda, Md. : 1985)
|March 18, 2005
PubMed
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Strenuous exercise reduces CD39 expression on platelets but increases it on B lymphocytes, impacting platelet activation and thromboregulation. This study highlights the role of CD39 (ATP diphosphohydrolase) in exercise physiology.

Area of Science:

  • Immunology and Exercise Physiology
  • Hematology and Thrombosis Research

Background:

  • CD39 (ATP diphosphohydrolase) is crucial for inhibiting platelet responsiveness and is found on various immune and blood cells.
  • The acute effects of strenuous exercise on CD39 expression in platelets and lymphocytes are not well understood.

Purpose of the Study:

  • To investigate the acute changes in CD39 expression on platelets and lymphocytes following strenuous exercise in both sedentary and active individuals.
  • To assess the impact of exercise on platelet activation markers.

Main Methods:

  • Eight healthy sedentary and eight physically active men underwent graded cycle ergometry to exhaustion.
  • Blood samples were analyzed pre- and post-exercise for CD39 expression on platelets and B lymphocytes.
  • Platelet activation was assessed by measuring platelet aggregates, ADP/collagen-induced aggregation, and expression of PAC-1 and CD62.

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Main Results:

  • All subjects showed significant platelet activation post-exercise, indicated by increased platelet-platelet aggregates.
  • ADP-induced platelet aggregation and CD62P expression increased in sedentary but not active subjects post-exercise.
  • CD39 expression significantly decreased on platelets and increased on B lymphocytes in all subjects after exercise.

Conclusions:

  • Strenuous exercise acutely alters CD39 expression on platelets and B lymphocytes, confirming its role in modulating platelet responsiveness.
  • The findings suggest a potential role for B lymphocytes in thromboregulation mechanisms influenced by exercise.