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The protein tyrosine kinase-dependent pathway mediates the effect of K intake on renal K secretion
Dao-Hong Lin1, Hyacinth Sterling, Wen-Hui Wang
1Department of Pharmacology, New York Medical College, Valhalla, New York, USA.
Abstract:
Dietary K intake plays an important role in the regulation of K secretion: a decrease stimulates and an increase suppresses kidney expression of protein tyrosine kinase (PTK), which plays a role in regulating Kir1.1 (ROMK), which is responsible for K secretion in the cortical collecting duct (CCD) and K recycling in the thick ascending limb. Tyrosine phosphorylation of ROMK channels increases with low dietary K and decreases with high dietary K. Moreover, stimulation of tyrosine phosphorylation of ROMK1 enhances ROMK1 internalization and reduces the K channel number in the cell surface in the CCD.
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