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Transient neurologic deficit after acetazolamide challenge for computed tomography perfusion imaging
Vaishali Choksi1, Marion Hughes, Linda Selwa
1Department of Radiology, University of Michigan, Ann Arbor, MI 48109-0030, USA. vrchoksi@med.umich.edu
Journal of Computer Assisted Tomography
|March 18, 2005
Summary
A patient experienced temporary neurological issues during a cerebral blood flow test using acetazolamide and CT perfusion imaging. This combination is useful for assessing brain blood vessel function but carries a risk of adverse reactions.
Area of Science:
- Neurology
- Radiology
- Medical Imaging
Background:
- Cerebrovascular steno-occlusive disease poses risks for cerebral hemodynamic impairment.
- Assessing cerebrovascular reactivity is crucial for managing patients with cerebrovascular disease.
Observation:
- A transient neurologic deficit occurred during acetazolamide challenge with dynamic enhanced computed tomography (CT) perfusion imaging.
- The patient had known cerebrovascular steno-occlusive disease.
Findings:
- The combined acetazolamide challenge and dynamic CT perfusion imaging is a rapid technique for evaluating cerebral hemodynamic impairment.
- This diagnostic approach can precipitate serious adverse events, such as transient neurologic deficits.
Implications:
- Clinicians must be aware of the potential for adverse neurologic responses when using this imaging technique.
- This case highlights the importance of monitoring patients closely during cerebrovascular reactivity testing.
- Dynamic CT perfusion imaging combined with acetazolamide challenge offers a valuable, albeit potentially risky, tool for assessing cerebral blood flow.