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Related Experiment Videos

When outside the norm is normal: interpreting lab data in the aged.

T A Cavalieri1, A Chopra, P N Bryman

  • 1Center for Aging, University of Medicine and Dentistry of New Jersey, School of Osteopathic Medicine, Stratford.

Geriatrics
|May 1, 1992
PubMed
Summary
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Aging affects many common laboratory test results, complicating interpretation in older adults. Further research is needed to establish age-specific reference ranges for elderly patients.

Area of Science:

  • Gerontology
  • Clinical Pathology
  • Internal Medicine

Background:

  • Common laboratory tests in primary care include complete blood count, arterial blood gases, erythrocyte sedimentation rate, creatinine clearance, and glucose tolerance.
  • Physiologic changes associated with aging can alter interpretation of laboratory data.
  • Interpreting lab data in the elderly is challenging due to comorbidities, polypharmacy, and atypical disease presentations.

Purpose of the Study:

  • To elucidate the impact of age-associated physiologic changes on the interpretation of frequently ordered laboratory tests.
  • To highlight the complexities in interpreting laboratory data in the elderly population.

Main Methods:

  • Review of existing literature on age-related changes in laboratory parameters.

Related Experiment Videos

  • Analysis of factors confounding laboratory data interpretation in older adults.

    • Main Results:

    • Advancing age leads to increases, decreases, or no change in many laboratory parameters.
    • The effect of age on some laboratory parameters remains unclear.
    • Multiple disease states, polypharmacy, and atypical presentations complicate interpretation.

    Conclusions:

    • Age-associated changes significantly impact laboratory test interpretation in the elderly.
    • Further clinical research is necessary to establish reliable reference laboratory values for elderly patients.