Related Experiment Video

Updated: Aug 19, 2026

Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment
07:29

Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment

Published on: April 22, 2019

[Medical oncology]

M S Aapro1

  • 1IMO, Clinique de Genolier, 1272 Genolier. maapro@genolier.net

Revue Medicale Suisse
|March 19, 2005
PubMed

Insights

Recent advances in medical oncology offer improved treatments for solid tumors. However, survival benefits vary, and rising drug costs challenge clinical adoption of promising new therapies.

Area of Science:

  • Oncology
  • Clinical Trials
  • Pharmacology

Context:

  • Rapid advancements in medical oncology are yielding new drugs for solid tumors.
  • Comparative trials are evaluating the efficacy of these novel therapeutic agents.
  • The clinical utility of some new cancer drugs is questioned due to marginal survival benefits and high costs.

Purpose:

  • To review the results of pivotal clinical trials in medical oncology.
  • To provide a clinically relevant context for interpreting trial data.
  • To aid clinicians in decision-making regarding the use of new cancer drugs.

Summary:

  • This review synthesizes findings from key clinical trials involving new drugs for solid tumors.
  • It highlights areas where significant survival improvements have been observed and where progress remains limited.
  • Data is presented to assist clinicians in assessing the value of promising, yet costly, oncologic therapies.

Impact:

  • Facilitates informed clinical decision-making in the management of solid tumors.
  • Addresses the challenge of integrating expensive novel therapies into patient care.
  • Contributes to a better understanding of the real-world benefits of recent oncologic drug development.

More Related Videos

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies08:34

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Published on: February 6, 2019

Related Concept Videos

Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Treatment Resistant Cancers02:56

Treatment Resistant Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Treatment Resistent Cancers02:56

Treatment Resistent Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...