Is spontaneous urinary visible chemiluminescence a reflection of in vivo oxidative stress?

Based on the characteristics of the visible spontaneous luminiscence of human urine, we propose that this luminescence is due to the dark decomposition of long-lived luminescent intermediates produced by oxidations at the cellular level, and that it might reflect the development of oxidative stress conditions in vivo. This hypothesis is consistent with the higher emission levels monitored in the urine of hyperthyroid patients and the correlation observed between urinary thiobarbituric acid reactive substances (TBARS) levels and urinary chemiluminescence.